![]() ![]() ![]() Administer a pre-intubation bolus of 1-2 mmol/kg sodium bicarbonate to avoid exacerbating acidosis, which will worsen symptoms.Requires endotracheal intubation if airway is at risk.Inhibits the mitochondrial cytochrome oxidase, which deranges ATP synthesisĮxtrapyramidal symptoms (in severe intoxication)Īcute renal failure (earlier in severe intoxication).Directly toxic to the retina which can cause visual disturbances and even blindness.Binds to calcium, forming insoluble calcium oxalate crystals, this can cause hypocalcemia and crystal deposition in several organs causing organ dysfunction.Toxicity of methanol and EG is related to the production of toxic metabolites by the hepatic enzyme alcohol dehydrogenase (ADH). ![]() Onset of symptoms of methanol poisoning can range from 40 minutes to 72 hours, depending on the dose and co-ingestion of ethanol.Methanol is present as a solvent in many household products, such as antifreeze, cleaning solutions, dyes, and paint removers.EG is a common component of antifreeze and de-icing solutions.Diagnose and treat intoxication with the toxic alcohols methanol and ethylene glycol (EG).Table of Contents Methanol and ethylene glycol poisoning Learning objectives ![]()
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